Is spinosad safe for dogs 5x the therapeutic dose) or with spinosad and milbemycin oxime at 5x the therapeutic dose showed no neurotoxic Trifexis is approved by the FDA as safe and effective when used according to the label. However, these studies are often observational and do not definitively prove a causal relationship. Safe use of Trifexis in male dogs intended for breeding has not yet been evaluated. 5x the therapeutic dose) or with spinosad and milbemycin oxime at 5x the therapeutic dose showed no neurotoxic Aug 8, 2023 · The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration Jul 6, 2021 · What Does Trifexis For Dogs Do? Trifexis spinosad milbemycin oxime can provide complete heartworm prevention for dogs. In 2004, Paul et al. Trifexis is an effective way to prevent heartworm disease in dogs. Mar 2, 2025 · COMFORTIS are for use in dogs and puppies 14 weeks of age and older (see ANIMAL SAFETY). This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Trifexis is not a recommended and/or approved product to give if your dog has already been diagnosed with heartworm disease. Oct 5, 2022 · Is Trifexis safe for dogs? As a preventative measure, Trifexis can be hugely beneficial. Feb 15, 2025 · Comment 10: “I use peppermint oil to freshen my dog’s breath. Each chewable tablet is formulated to provide a minimum spinosad dosage of 13. 6%), and diarrhea (2. Families with children or other pets, since there is no transfer of product through contact Dec 8, 2024 · Dogs who frequent boarding facilities, daycare, dog parks, or other areas with many dogs are at a higher risk of contracting kennel cough, so this vaccine is particularly important for social dogs. Your cat needs to be approximately 3 to 4 months old before it is generally considered safe to apply spinosad for cats. Spinosad works by causing an overload of nicotinic acetylcholine receptors in the insect’s nervous system. Sep 24, 2013 · You should note that individual dogs may react differently to medications, and what is safe for one dog may not be for another. Like all medications, keep Trifexis out of reach of children. Comfortis starts killing fleas within 30 minutes and provides a full month of protection against flea infestations. Safety was shown in puppies 14 weeks of age and older and adult dogs in both laboratory studies and clinical field studies. 1-40 lbs; Comfortis® for Dogs 40. Oct 11, 2024 · Spinosad is FDA-approved for use in dogs, puppies, cats, and kittens. If storage is a top concern for you, Sundays for Dogs is the easiest to manage. 5 mg milbemycin Unfortunately not. Before starting Comfortis™ PLUS, you should have your veterinarian confirm that your dog does not have heartworm; The following adverse events have been recorded following administration of spinosad and milbemycin together: vomiting, pruritus, lethargy and diarrhoea; In some animals, Comfortis™ PLUS may be associated with vomiting. g. 1-60 lbs (blue) contains 810 mg spinosad and 13. Continued monthly use of TRIFEXIS can prevent any Suitable for Dogs and Puppies: Trifexis is safe for dogs and puppies 8 weeks of age and older, weighing at least 5 pounds. Fleas that bite the dog are exposed to spinosad, which leads to their rapid demise. 7% given afoxolaner and 61. Use with caution in dogs with pre-existing epilepsy (see ADVERSE REACTIONS). Spinosad is highly selective for insect receptors. Use only for cats and kittens 14 weeks of age or older and 4. Trifexis is safe for use in puppies as young as 8 weeks of age. Is it safe to cut Trifexis in half? No, it is not safe to cut Trifexis in half. Oct 9, 2024 · Milbemycin/spinosad (Trifexis) is a combination medicine to kill fleas, prevent heartworms, and control intestinal parasites (roundworms, hookworms, and whipworms) in dogs and puppies. One essential aspect of pet care is protecting them from parasites, such as fleas, ticks, and heartworms. It is FDA Spinosad is an oral flea adulticide that is used in the prevention and treatment of flea infestations in dogs and cats. 8% of fluralaner treated pets experienced a reaction; whereas 68. 1-6 lbs (140 mg), Orange box for dogs 10. Facebook is another source of information about the side effects of these chewable drugs. The formulation is designed to be palatable, making it easier for dogs to consume. How Does Trifexis Work? Trifexis is approved by the FDA as safe and effective when used according to the label. Puppies under 14 weeks old might vomit at a higher rate than older puppies and dogs. When a dog ingests Comfortis, the active ingredient spinosad is absorbed into the bloodstream. While it’s an effective and convenient solution, many dog owners have concerns about potential long-term side effects. Puppies: Trifexis is generally safe for puppies over eight weeks old and weighing at least five pounds. Spinosad is low in toxicity to people and other mammals. You only have to give one chewable tablet every 30 days. Ivermectin is not recommended for use in puppies under 6 weeks of age, so Heartgard should be started at this age and not sooner. 5 mg/lb (30 mg/kg). Trifexis is a tablet designed to be administered as a whole. May 15, 2023 · Trifexis is a popular medication used for the prevention and treatment of certain parasites in dogs. 6% recorded some type of reported AE (Table 1). 1 to 20 lbs and cats 6. Trifexis continues to kill fleas for a full month after treatment. As a heartworm medication, Trifexis kills fleas and even prevents heartworm disease, whipworm infections, flea allergy dermatitis, adult fleas, kills fleas and prevents heartworm disease, flea prevention, adult whipworm, intestinal worms, and any other flea problem. 3 mg milbemycin oxime; for dogs 10. Both products are safe for dogs when following directions. For Small to Large Dogs: Available in various doses, including Trifexis green, ensuring the right dosage for different dog sizes. Advantages of Trifexis® for Dogs: Milbemycin oxime works to kill adult whipworms, roundworms, and hookworms; Milbemycin oxime prevents heartworms and kills immature heartworms; Proven to kill 100% of biting fleas; Starts working in just 30 minutes; Spinosad targets nAChRS (nicotinic acetylcholine receptors) of insects; Convenient, single Is it safe to give my dog COMFORTIS? COMFORTIS has been demonstrated to be safe in pure and mixed breeds of healthy dogs when used according to label directions. One dog that received a moderate dose vomited. Feb 26, 2025 · Ivermectin is commonly used in dogs to prevent heartworm disease and to treat various types of parasitic infections. 1-24 (560 mg), Blue box for dogs 40. “Trifexis is a good and safe preventive Use with caution with concomitant extra-label use of ivermectin. Despite being an FDA approved drug, many users have complained about side effects of Trifexis for dogs. Trifexis is developed exclusively for administration on dogs and puppies. Oct 1, 2024 · TRIFEXIS has been demonstrated to be safe in pure and mixed breeds of healthy dogs when used according to label directions for dogs and puppies 8 weeks of age and older and five pounds of body weight or greater. 1% of sarolaner treated dogs had a reaction following these treatments. Administer cautiously to epileptic dogs. It is a combination of two active ingredients, spinosad and milbemycin oxime, which work together to provide comprehensive protection against fleas, heartworms, intestinal worms, and other parasites. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. In this guide, we will delve into everything you need to know about Trifexis, including its benefits Yes. May 16, 2022 · Trifexis ® (spinosad in combination with milbemycin oxime) is approved for puppies age 8 weeks and older. Why use Trifexis Chewable Tablets for Dogs? – Trifexis chewable tablets kill fleas before they lay eggs and kill biting fleas within 30 minutes of administration. The dosage of Trifexis is based on a dog’s weight. Use with caution in breeding females (see ANIMAL SAFETY). The general dosage guideline for dogs is to administer spinosad orally at a minimum dose of 30 mg/kg (13. Comfortis is: Comfortis is: Convenient. The two components of Trifexis for dogs are spinosad + milbemycin oxime. If your dog has had trifexis before then I would not worry and continue it on your normal schedule. Mar 5, 2021 · Dogs: Spinosad is dosed according to the weight of the dog. These new fleas will be killed before they can produce eggs that contaminate the environment. Trifexis is approved by the FDA as safe and effective when used according to the label. Spinosad Price Dec 9, 2024 · Dog dental powders are becoming increasingly popular as an easy way to maintain canine oral hygiene. Unlike The Farmer’s Dog and Freshpet, which both require refrigeration or freezer space, Sundays is air-dried and shelf-stable, meaning it can sit in your pantry like dry kibble but with much better nutritional value. Pharmacokinetics of spinosad Jul 6, 2016 · If your dog vomits within an hour of taking their tablet, talk to your vet; you may need to administer another dose to make sure your dog gets the medicine he or she needs. Understanding how Trifexis works can help pet owners make informed decisions about their furry Jan 1, 2024 · Trifexis is generally safe for dogs, but it is important to remember that every dog reacts differently. Jul 22, 2024 · What Is Comfortis® for Dogs and Cats? Comfortis® is a chewable prescription medication for dogs and cats to treat and prevent flea infestations. Aug 7, 2020 · Although spinosad is felt to be safe when used with other flea and heartworm medications, serious adverse effects have been noted with the use of ivermectin (at high doses required to eliminate parasites like demodectic mange) and spinosad alone. The safe use of TRIFEXIS in male dogs intended for breeding has not been evaluated. Spinosad for Cats. Milbemycin oxime + spinosad is safe for use in most dogs. This vet's guide explains what you must know about flea pills for dogs, how to buy them and more. 3 mg milbemycin oxime; for dogs 40. Nov 16, 2024 · While Trifexis is generally considered safe and effective, some studies have suggested a possible link between avermectin-class drugs, like milbemycin oxime, and certain types of cancer in dogs. For dogs treated with an isoxazoline, 86. Trifexis is NOT intended for use on cats. spinosad remains safe for use with low doses of ivermectin found in Aug 4, 2020 · If you have a 15 pound dog, for example, you should stick to the Trifexis medication for 10 to 20 pound dogs. Sep 17, 2013 · When Trifexis is Safe for Your Dog From K9 Advantix II to Frontline Plus, there are numerous flea medications available for dog owners to choose from. This drug combination should not be used in dogs who are allergic to any component of the product or in dogs that are heartworm positive or have not recently been tested. Trifexis is a popular medication that provides comprehensive protection against these common parasites. Singler explains, who recommends regular (once a month) medication when furry family members are 8 weeks of age or older. Is Comfortis Safe for Dogs? Each chewable tablet for dogs 5-10 lbs (pink) contains 140 mg spinosad and 2. In a field study of client-owned dogs where 175 dogs were each offered TRIFEXIS once a month for 6 months, dogs voluntarily consumed 54% of the doses when offered plain as if a treat, and 33% of the doses when offered in or on food. Sep 30, 2024 · Heartgard and Heartgard Plus are considered safe for most dogs, including pregnant and breeding dogs, but there are some exceptions. With Trifexis, you can play with your dog immediately after treatment. If she has never had it before, I would choose a different type of heart worm and flea prevention because the most common side effect is vomiting. Mar 14, 2024 · Both Trifexis and Simparica Trio are known to be safe and effective for most dogs, and are widely prescribed and used by pet parents and the veterinary community. This concept is somewhat similar to how the antibiotic penicillin was originally derived from the Penicillium fungal mold. Feb 21, 2024 · Trifexis for Dogs – Is It Safe? Dogs bring us immeasurable joy and companionship–making our lives richer in countless ways. Cat owners, like dog owners, often rely on spinosad products, such as Comfortis for cats, to treat fleas on their furry buddies. It’s also quite safe for good insects such as adult butterflies and bees. To ensure heartworm prevention, dogs should be observed for one hour after administration. This beef-flavored, chewable tablet combines spinosad and milbemycin oxime , two potent active ingredients that kill fleas and prevent infestations while also May 14, 2024 · Is Nexgard Safe For Dogs? Is Bravecto Safe For Dogs? What Dog Owners Say About Chewable Flea and Tick Preventives. 1 lbs of body weight or greater, and for dogs and puppies 14 weeks of age and older and 5. Cats and dogs: Type of tablet: Chew: Flavor: Beef: Comfortis is a safe and effective flea treatment for cats Spinosad, the primary ingredient in Trifexis, begins to work in 30 minutes and is proven to kill 100% of all biting fleas. Spinosad; Spironolactone; Use in ABCB1-Positive Dogs. Comfortis and Trifexis. Always follow your veterinarian’s dosage recommendations. Trifexis is for dogs and puppies 8 weeks of age or older. 1 to 60 lbs (810 mg), and Brown box for dogs 60. Trifexis® should not be used in animals with known hypersensitivity or allergy| to the drug. Nov 21, 2022 · How Trifexis® Works. No effects related to spinosad were observed in the other dogs. 1-12 lbs (270 mg), Green box for dogs 20. Can Trifexis be given to cats? Nov 9, 2022 · Always discuss any medications your pet is taking with your veterinarian prior to starting your dog on Trifexis. – Trifexis treats and controls roundworms, hookworms, and Dec 7, 2024 · Yes, giving Cosequin and Movoflex together is typically safe for many dogs, but professional guidance is crucial. Trifexis is easy to give to your dog, as it comes in chewable tablets. Apr 14, 2023 · The active drug in Comfortis is called spinosad. Trifexis has been demonstrated to be safe in healthy dogs when used according to label directions. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. It Jul 13, 2021 · Spinosad can be problematic when used in dogs with the MDR-1 mutation (e. It is also used in tablets and pills for oral administration to dogs against fleas. Spinosad is a member of the class of insecticides called spinosyns, which are actually derived from a naturally occurring bacterium called Saccharopolyspora spinosa. Feb 16, 2024 · Not all dog flea preventatives are safe and/or effective. Sep 16, 2024 · Trifexis (spinosad / milbemycin oxime) is a safe and effective monthly parasite preventative for dogs. Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study. Disclaimer: even parasite protection products officially labeled safe – for an MDR1 dog or any dog – should really be designated “safe-ish. If your dog vomits within 1 hour of dosing, another dose may be administered. Trifexis should not be used on puppies or dogs under 5 lbs. found that moxidectin/imidacloprid topical solution was safe for use at doses up to 5 times the recommended dose even in ivermectin-sensitive collies. Oct 10, 2017 · Yes. Apr 22, 2024 · Comfortis® for Dogs 5-10 lbs; Comfortis® for Dogs 10. This flavored chew is given once a month to help combat fleas. 0 lbs of body weight or greater. Spinosad, one of its active ingredients, is produced by a bacterium first isolated from natural sources (a soil sample collected in the Caribbean). Beyond vaccination, limiting your dog’s exposure to environments where respiratory infections are prevalent can reduce their risk. While these powders can help reduce plaque and tartar, they’re not without their potential drawbacks. 1 Jul 16, 2021 · There are reports on good efficacy against cattle ticks (Boophilus microplus) but commercial products are not yet available for this indication. The safe use of Comfortis in breeding, pregnant, or lactating cats has not been evaluated. Trifexis is proven safe in dogs and puppies 8 weeks and older and 5 pounds and greater. Sentinel contains milbemycin oxime and lufenuron, while Trifexis contains spinosad and milbemycin oxime. 6 mg/lb) once a month. Trifexis is not for use in humans. Key Takeaways: Quick Answers to Spinosad is a chewable tablet that kills adult fleas and treats dermatitis in dogs. Trifexis Mar 11, 2023 · Trifexis is a drug for dogs that’s achieved a wide degree of popularity … as well as notoriety. The most common adverse reactions reported are vomiting, depression/lethargy, pruritus, anorexia, and diarrhea. The safe use of Trifexis® in breeding males has not been evaluated. Consult your veterinarian before using Trifexis in these situations. Even when consumed with food, spinosad breaks down easily and comes out of the body naturally within a day or two without having any harmful effects. When fleas jump onto your dog, they will be killed by TRIFEXIS. However, unlike Bravecto, Trifexis has not yet been evaluated for use in breeding, pregnant, or lactating dogs. . 0 pounds or heavier. While both Sentinel and Trifexis have a similar safety profile, they contain different active ingredients. It primarily serves to prevent fleas and ticks and protects against heartworm disease. Trifexis for Dogs 60-120 lbs is a veterinary-recommended, broad-spectrum parasite protection that safeguards large dogs from fleas, heartworm disease, and common intestinal worms. How safe is spinosad? Spinosad is a natural insecticide that is safe for both humans and pets. 1-60 lbs; Comfortis® for Dogs 60. It is also used in human medicines against lice (pediculosis). Is there a safe way to do this?” Bad breath in dogs is often a sign of dental disease rather than something that can be masked with peppermint oil. To ensure heartworm prevention, observe your dog for one hour after administration. The safe use of Trifexis in breeding males has not been evaluated. This will help prevent drug interactions and ensure safety. 3%). 5 mg milbemycin oxime; for dogs 20. Is Trifexis safe for dogs? However, if it gets on your skin or in your eyes it can cause irritation and redness. Important Trifexis is approved by the FDA as safe and effective when used according to the label. The safe use of COMFORTIS in breeding males has not been evaluated. COMFORTIS (spinosad) is available in six sizes of chewable flavored tablets for oral administration to dogs and puppies according to their weight. Trifexis is the #1 prescribed combo parasite protection … meaning it can protect against fleas, heartworms and intestinal worms. Nov 10, 2024 · Pregnant and Lactating Dogs: The safety of Trifexis in pregnant or lactating dogs has not been fully established. In one study, 28 dogs were fed low to moderate doses of spinosad. Dogs who will be bred or who are pregnant or nursing should not, in most cases, take Trifexis. It combines two powerful ingredients, spinosad (which kills fleas) and milbemycin oxime (which prevents heartworms and intestinal worms). Just treat and play! Trifexis is an ideal choice for. Dec 6, 2024 · Trifexis is a popular medication used to protect dogs from heartworm, fleas, and intestinal parasites. Key Takeaways: Quick Answers About Dog Dental Powder Side Effects 📝 Are dental powders safe for dogs? Generally, yes, when used as directed. Trifexis comes in a chewable, beef-flavored tablet that dogs should take once every 30 Jul 13, 2021 · Spinosad can be problematic when used in dogs with the MDR-1 mutation (e. Pharmacokinetics of spinosad Trifexis has been demonstrated to be safe in healthy dogs when used according to label directions. Families with children or other pets, since there is no transfer of product through contact Of the 1594 dogs receiving any brand of flea & tick remedy 66. Is there a difference between Comfortis for dogs and for cats? They work the same for dogs and for cats. Keep your canine companions happy and healthy with Trifexis®. There is no need to isolate your pet. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. However, if it gets on your skin or in your eyes it can cause irritation and redness. When it comes to eliminating fleas on your dog or cat, you want a flea medicine you can trust. Each has its own benefits and possible side effects that can impact your canine's health. Safe use in breeding, That insecticide is spinosad. Answer: Trifexis is safe for use in senior dogs, but it is crucial to consider any age-related health concerns that may affect the safety and efficacy of the medication. Here’s why vet consultation is recommended: Different Active Ingredients : Cosequin usually contains glucosamine , chondroitin , and MSM (Methylsulfonylmethane) , while Movoflex includes BIOVAFLEX Egg Shell Membrane , Hyaluronic What is Trifexis® (spinosad + milbemycin oxime)? Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infection in dogs. Spinosad starts to kill fleas in 30 minutes in dogs and cats. Chewable tablets are designed to be palatable and can be offered directly to the dog or mixed with food. Nevertheless, tolerance studies have shown that dogs sensitive to ivermectin treated with spinosad at 300 mg/kg (~4. However, alongside the love and companionship they offer, our canine friends can also face health challenges that require our attention and care. The major side effect in both species is vomiting, which can be treatment limiting in some individuals. 16 However, this effect has not been Comfortis is available in a Pink box for dogs 5 to 10 lbs and cats 4. The remaining 13% of doses were administered like other tablet medications. Cutting it in half may alter the effectiveness of the medication and can also lead to improper dosing. I have a small dog, can I cut Trifexis in half to give him a smaller dose? Jan 22, 2025 · What is Trifexis? Trifexis is a veterinary prescription medication designed for dogs, combining two active ingredients: spinosad and milbemycin oxime. Precautions Not proven safe for use in breeding female dogs. Dec 6, 2024 · Which Brand Is Best for Storage Convenience? Sundays Wins for Shelf-Stable Simplicity. 5x the therapeutic dose) or with spinosad and milbemycin oxime at 5x the therapeutic dose showed no neurotoxic Comfortis has demonstrated to be safe in healthy dogs and cats when used according to label directions. Jan 7, 2025 · Comfortis is a flea tablet containing Spinosad made by Elanco Animal Health. Trifexis kills adult fleas and is proven to treat and control tick infestations. 1-120 lbs; Q6: How Often Should Comfortis® Be Administered? A: Comfortis® is typically administered once a month for ongoing flea prevention and treatment. Learn about its benefits, side effects, and how to use it safely. Mar 2, 2025 · TRIFEXIS is a flavored chewable tablet. “All dogs should be on parasite prevention, including heartworm prevention,” Dr. Trifexis® should not be given to dogs with allergies to soy or pork as the pill is flavored. Mar 12, 2024 · For pet owners, keeping our furry companions healthy and protected is a top priority. Spinosad is FDA-approved for use in dogs, puppies, cats, and kittens. Comfortis® For Dogs is approved for use in dogs and puppies 14 weeks of age and older and 5. If your dog or cat has fleas, you need the brand Comfortis, or generic medical name spinosad. Pet medications need prescriptions. Trifexis is available in five different sizes, so you can choose the right size for your dog. Collies), as all macrocyclic lactones. 16 Spinosad should be administered with caution (or avoided entirely) in dogs with preexisting seizure disorders because seizures have been associated with administration of this drug in these dogs. americanum infestations for one month in dogs and puppies 8 weeks of age and environment. It offers protection against fleas, heartworms, roundworms, hookworms, and whipworms in a once-monthly flavored tablet. Other possible side effects of Trifexis include itching (affecting about 4% of dogs), lethargy (2. Key Takeaways: Quick Answers to Nov 23, 2020 · 1-800-PetMeds states Trifexis should only be prescribed to dogs at least eight weeks old and with a weight of at least five pounds. Comfortis ® (spinosad) is the first FDA-approved, chewable, beef-flavored tablet that kills fleas and prevents flea infestations on dogs for a full month. 1 to 40 lbs and cats 12. Trifexis ® has two active ingredients, spinosad and milbemycin oxime. What side effects might occur with TRIFEXIS? Like all medications, sometimes side effects may occur. Protect your dogs and cats from fleas, heartworms, hookworms, roundworms and whipworms with Trifexis chewable tablets. Use with caution in breeding females. Spinosad can be problematic when used in dogs with the MDR-1 mutation (e. Trifexis for Heartworm Prevention. Initial testing included use in dogs with pre-existing seizure disorders with doses higher than the recommended dose. It begins to kill fleas in about 30 minutes and kills up to 100% of fleas on dogs within 4 hours. Instead of using a potentially toxic essential oil, opt for dog-safe alternatives that target the root cause of bad breath. It’s crucial to maintain a Aug 18, 2015 · While generally safe and effective when prescribed by a veterinarian, Trifexis® can cause side effects in some animals. See Comfortis label for complete safety information. 1-40 lbs (green) contains 560 mg spinosad and 9. Use with caution in dogs with a history of seizures or neurologic disorders. These group pages contain many tragic stories from dog owners who believe their dogs have been harmed by these pest preventives. Safe to Use During Breeding/ Lactation Food Milbemycin oxime + spinosad: and A. Comfortis ® (spinosad alone) is approved for puppies and kittens 14 weeks of age and older. It is safe for use in puppies who are 8 weeks of age or older and at least 5 pounds . Some of these dogs broke Is it safe to give my breeding dogs TRIFEXIS? Ask your veterinarian about the use of TRIFEXIS prior to use in breeding females. Your veterinarian can help determine the best flea and heartworm prevention plan for your senior dog . However, Simparica Trio and other drugs in the isoxazoline class come with an FDA warning regarding the potential for neurological side effects, including tremors, incoordination, and For many dogs, that’s around 2 months old. Prior to use, dogs should have a negative heartworm test. Adverse Reactions Jan 24, 2025 · Trifexis® official website. Jan 8, 2025 · Is Trifexis Safe to Give in a Heartworm-Positive Dog? No. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. FOR DOGS: The most common adverse reaction reported is vomiting. If within a month after your dog receives TRIFEXIS you see fleas on your dog, it is most likely that these are new fleas. ” But parasite preventives are chemical compounds – some of which are used in pesticides – and thus have more potential to cause a reaction than just, well, water. Trifexis Dosage for Dogs. 1 to 120 lbs (1620 mg). 1-20 lbs; Comfortis® for Dogs 20. Side effects of Trifexis include vomiting, diarrhea, and lethargy, with vomiting being the most common. 1-20 lbs (orange) contains 270 mg spinosad and 4.
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